Data security in mobile healthcare

Introduction/purpose: The digitization of healthcare has gained particular importance in the years since the emergence of COVID-19 and also has become one of the primary goals of the Government of the Republic of Serbia. Telemedicine is a good solution when the patient cannot come to a healthcare facility. Mobile healthcare applications are already widely used, but in both fields the important challenge is data security. The aim of this paper is to review solutions for data security in mobile healthcare from the technical side and possible challenges in the process of digitization of the healthcare system in Serbia. Methods: This review is based on current papers in this area, on the available relevant literature and the authors' many years of experience in this field. Experiences in the process of digitization of healthcare in Serbia are based on available articles and regulations. Finally, possible challenges are presented from the authors' perspective based on everything presented in the field of data security in mobile healthcare. Results: The analysis of the papers reviewed from the point of view of data security showed that users are often ready to sacrifice their privacy for the sake of convenience provided by mobile applications. Conclusion: Based on the review of the papers and clear data security requirements that include the presented safeguards, one of the main tasks of the entire community is to raise awareness of information security and awareness of the need for cyber hygiene of each individual, which is the basis for the safe use of e-health services

Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis

In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease

Effect of physostigmine and verapamil on active avoidance in an experimental model of Alzheimer's disease

The present study was performed to investigate and compare the effect of acetylcholinesterase inhibitor, physostigmine (0.045, 0.060 and 0.075 mg/kg sc, 30 min before the tests) and Ca-antagonist, verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg sc, 30 min before the tests), on two-way active avoidance (AA) learning (acquisition and performance) in nucleus basalis magnocellularis (NBM)-lesioned rats. Bilateral electrolytic lesions of NBM induced significant decrease of acquisition and performance of AA responses in rats. Physostigmine (0.060 mg/kg) significantly improved only acquisition of AA, while verapamil (2.5 and 5.0 mg/kg) significantly improved both type of AA behavior in NBM-lesioned rats. These results suggest that altered calcium homeostasis might play significant role in pathogenesis of experimental induced Alzheimer's disease (AD) and that administration of calcium antagonist such as verapamil might successfully ameliorate disturbances of learning and memory appeared after lesions of NBM